Outlet of Prognostic Value of Preoperative Cardiac Troponin I

left ventricularFrom January 2001 to September 2004, preoperative cTnI was measured in 1,978 consecutive patients scheduled for isolated CABG. Preoperative cTnI values were available in 1,978 of 3,124 patients who fulfilled the inclusion criteria and in whom primary isolated CABG had been performed. Among these patients, negative preoperative cTnI levels ( 1.5 ng/mL) [Fig 1].

There were no significant differences between most perioperative patient characteristics of the remaining 1,146 CABG patients, who were initially not enrolled into the study due to no preoperative cTnI measurements, except a lower incidence of smoking history, preoperative hemodialysis-dependent renal disease, and postoperative arrhythmias, compared to group 1 patients, as well as a lower incidence of preoperative hemodialysis-dependent renal disease and postoperative IABP support compared to the entire patient cohort with preoperative cTnI measurements.

Research about Prognostic Value of Preoperative Cardiac Troponin I

low cardiac output syndrome

Clinical End Points

The primary end point of the study was in-hospital mortality, defined as death from any cause within 30 days after surgery or during the same time period of hospitalization as well as postoperative MACE during the period of hospitalization including perioperative MI (PMI) and low cardiac output syndrome (LCOS). Secondary study end points were other postoperative complications such as stroke, new-onset ventricular arrhythmia, major bleeding, necessity for rethoracotomy, and postoperative renal failure requiring temporary hemodialysis.

Selection of Patients

Patients were enrolled into the present study if they had undergone an isolated CABG procedure and a preoperative cTnI serum level had been obtained 24 h before surgery (Table 1). For risk analysis, patients were stratified into three groups according to preoperative cTnI levels, as previously described. Among these, 1,592 patients had negative preoperative cTnI serum levels 1.5 ng/mL (group 3).